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Role of nitric oxide in the pathogenesis of dengue. / Anez, German;Valero, Nereida;Mosquera, Jesus

Tác giả : Anez, German;Valero, Nereida;Mosquera, Jesus

Nhà xuất bản : WHO Regional Office for South-East Asia.

Năm xuất bản : 2007

Chủ đề : 1. Dengue Virus. 2. Nitric Oxide. 3. Severe Dengue. 4. Journal / periodical articles.

Thông tin chi tiết

Tóm tắt :

Dengue Bulletin. 2007 Dec; 31: 118-123. The free radical nitric oxide (NO) has emerged in recent years as a fundamental signalling molecule for the maintenance of homeostasis, as well as a potent cytotoxic effector involved in the pathogenesis of a wide range of human diseases. The presence of NO during dengue infection as well as its experimental antiviral and apoptotic effects have been documented. In this regard, increased serum NO levels in dengue fever and basal levels in the haemorrhagic form of dengue have been reported. Clinical and experimental data suggest that NO could act as a beneficial factor during dengue infection by its antiviral and apoptotic effects; however, more intense investigations are required.

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https://iris.who.int/handle/10665/170367