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  • Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever. / Ernawati Dewi, Beti;Takasaki, Tomohiko;Sudiro, T. Mirawati;Nelwan, R.H.;Kurane, Ichiro
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Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever. / Ernawati Dewi, Beti;Takasaki, Tomohiko;Sudiro, T. Mirawati;Nelwan, R.H.;Kurane, Ichiro

Tác giả : Ernawati Dewi, Beti;Takasaki, Tomohiko;Sudiro, T. Mirawati;Nelwan, R.H.;Kurane, Ichiro

Nhà xuất bản : WHO Regional Office for South-East Asia.

Năm xuất bản : 2007

Chủ đề : 1. Endothelium. 2. Intercellular Adhesion Molecule-1. 3. Severe Dengue. 4. Journal / periodical articles.

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Dengue Bulletin. 2007 Dec; 31: 103-110. The pathological mechanism of dengue haemorrhagic fever (DHF) is still poorly understood. Previous studies have suggested that immune responses contribute to an increase in capillary permeability. We examined the levels of cytokines and activated endothelial substances in serum samples collected from DHF patients in Indonesia. We measured the levels of soluble TNF-R1, MCP-1, GM-CSF, IL-17, TNF-α, soluble thrombomodulin, soluble E-selectin, soluble ICAM-1 and soluble VCAM-1. The levels of activated endothelial substances such as sE-selectin, sICAM-1 and sVCAM-1 were higher in DHF patients than in healthy controls. High levels of soluble activated endothelial substances suggest that endothelial cells are highly activated. When compared with patients with other febrile illness (OFI) or healthy controls, the levels of sTNF-R1 were higher in DHF patients. A similar trend was observed in the level of thrombomodulin. MCP-1, GM-CSF and IL-17 were not detected in serum samples from any patients and healthy controls. TNF-α was detected in 5(9%) of 53 patients. The results suggest that endothelial cells are highly activated in DHF patients and TNF-α is one of the factors which contributes to the activation.
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https://iris.who.int/handle/10665/170398

 

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Detection of Dengue Virus Serotype-specific IgM by IgM Capture ELISA in the Presence of Sodium thiocyanate (NaSCN). / Nawa, Masaru;Takasaki, Tomohiko;Ito, Mikako;Kurane, Ichiro;Akatsuka, Toshitaka

Tác giả : Nawa, Masaru;Takasaki, Tomohiko;Ito, Mikako;Kurane, Ichiro;Akatsuka, Toshitaka

Nhà xuất bản : WHO Regional Office for South-East Asia

Năm xuất bản : 2004

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Development of IgM-capture Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Dengue using Beta-propiolactone-inactivated Dengue Viral Antigens. / Nawa, Masaru;Takasaki, Tomohiko;Yamada, Ken-Ichiro;Kurane, Ichiro;Akatsuka, Toshitaka

Tác giả : Nawa, Masaru;Takasaki, Tomohiko;Yamada, Ken-Ichiro;Kurane, Ichiro;Akatsuka, Toshitaka

Nhà xuất bản : WHO Regional Office for South-East Asia

Năm xuất bản : 2003

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The Features of Imported Dengue Fever Cases Confirmed at National Institute of Infectious Diseases Japan, During 2001. / Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, kinjiro;Kurane, Ichiro

Tác giả : Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, kinjiro;Kurane, Ichiro

Nhà xuất bản : WHO Regional Office for South-East Asia

Năm xuất bản : 2003

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The Features of Imported Dengue Fever Cases Confirmed at National Institute of Infectious Diseases Japan, during 2001. / Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, Kinjiro;Kurane, Ichiro

Tác giả : Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, Kinjiro;Kurane, Ichiro

Nhà xuất bản : WHO Regional Office for South-East Asia

Năm xuất bản : 2002

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The features of imported dengue fiver cases confirmed at National Institute of Infectious Diseases Japan, during 2001 / Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, Kinjiro;Kurane, Ichiro

Tác giả : Yamada, Ken-Ichiro;Takasaki, Tomohiko;Nawa, Masaru;Nerome, Reiko;Arai, Yohko T;Morimoto, Kinjiro;Kurane, Ichiro

Nhà xuất bản : WHO Regional Office for South-East Asia

Năm xuất bản : 2002