
Toxic oil syndrome: current knowledge and future perspectives / World Health Organization. Regional Office for Europe
Tác giả : World Health Organization. Regional Office for Europe
Nhà xuất bản : World Health Organization. Regional Office for Europe
Năm xuất bản : 1992
ISBN : 9289013052 (print); 9789289013055 (print)
Tùng thư :
WHO Regional Publications, European Series
Chủ đề : 1. Brassica -- toxicity. 2. Food Safety. 3. Foodborne Diseases -- etiology. 4. Plant Oils. 5. Spain. 6. Publications.
Thông tin chi tiết
Tóm tắt : | This publication provides a collection of six reviews summarizing current research on the epidemiology, etiology, pathogenesis and clinical pathology of the toxic oil syndrome. Over 700 investigations, including numerous unpublished reports, were critically assessed. Although contaminated rapeseed oil has been identified as the vehicle of the causative agent, the agent itself has not yet been identified and the mechanisms of pathogenicity remain unknown. The first chapter reviews epidemiological findings from studies designed to determine the causal agent, the factors that influenced individual susceptibility, and the long-term evolution of disease manifestations. The second chapter presents the results of a systematic 31-month follow-up of the clinical status of patients. Problems discussed include the failure of all currently available treatments and the need to explain why disability is progressive in some patients, while others gradually improve. Other chapters summarize what has been learned from autopsy studies and surgical specimens about the pathology of the disease, present the results of various efforts to replicate the disease in experimental models and summarize available data on the chemical composition of contaminated oils. The final chapter explores the involvement of immunological mechanisms in the disease, drawing direction from the similarity of symptoms to those seen in graft-versus host disease and in hydantoin-induced autoimmunity. The book concludes with an outline of further research needed. xvii, 163 p. |
Thông tin dữ liệu nguồn
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https://iris.who.int/handle/10665/260458 |