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  • Detection of dengue virus serotype 4 in Sudan / Mohamed Desogi;Mostafa Ali;Nesrin Gindeel;Fatima Khalid;Muhannad Abdelraheem;Aymen Alnaby;Mariam Saad;Elwaleed Elamin;Musa Kheir;Maowia M. Mukhtar
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Detection of dengue virus serotype 4 in Sudan / Mohamed Desogi;Mostafa Ali;Nesrin Gindeel;Fatima Khalid;Muhannad Abdelraheem;Aymen Alnaby;Mariam Saad;Elwaleed Elamin;Musa Kheir;Maowia M. Mukhtar

Tác giả : Mohamed Desogi;Mostafa Ali;Nesrin Gindeel;Fatima Khalid;Muhannad Abdelraheem;Aymen Alnaby;Mariam Saad;Elwaleed Elamin;Musa Kheir;Maowia M. Mukhtar

Nhà xuất bản : World Health Organization. Regional Office for the Eastern Mediterranean

Năm xuất bản : 2023

Chủ đề : 1. Cities -- epidemiology. 2. Communicable Diseases. 3. Disease Outbreaks. 4. Serogroup. 5. Sudan. 6. Journal / periodical articles.

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Background: Dengue virus infection is spreading globally and most parts of Sudan have witnessed repeated dengue outbreaks, with the detection of DENV-1, DENV-2 and DENV-3 serotypes. Aims: In this report we describe the dengue fever outbreaks that occurred in eastern Sudan (Kassala and Port Sudan cities) from August to November 2019. Methods: We enrolled 79 (29.8%) suspected cases from Kassala and 186 (70.2%) from Port Sudan who presented with fever. The participants were medically examined and their clinical signs recorded. Blood samples were collected for complete blood count, detection of anti-dengue virus IgM, detection of NS1 dengue antigen and identification of the virus serotype using RT-PCR. Results: The main clinical presentations were fever, abdominal pain, joint pain and vomiting, and thrombocytopenia was the main laboratory finding. One hundred and twenty-five blood samples tested positive for the anti-dengue IgM antibody, and 145 were positive for the NS1 antigen. Using RT-PCR, we identified 35 (24%) infections with DENV-2, 100 (69%) with DENV-3 and 10 (7%) with DENV-4 serotypes. Conclusions: We identified multiple serotypes – DENV-2, DENV-3 and DENV-4 – as the causes of the outbreak. The presence of DENV-4 serotype was documented for the first time in Sudan.
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https://iris.who.int/handle/10665/380967