loading
Sách, tuyển tập

Isolating and Screening Mangrove Microalgae for Anticancer Activity / N. H. Tri

Tác giả : N. H. Tri

Nhà xuất bản : Research Journal of Phytochemistry

Năm xuất bản : 2011

Chủ đề : 1. Amphiprora alata. 2. Ankistrodesmus gracilis. 3. Anticancer Activity. 4. Mangrove Mivroalgae. 5. Screening. 6. Article.

Chia sẻ

Thông tin chi tiết

Tóm tắt :

Microalgae are valuable source of many unique biologically active compounds including anticancer compounds. In this study, sixteen microalgal strains were successfully isolated from mangrove in Xuanthuy National Park, Namdinh, Vietnam. Relative identification for each train was obtained based on morphological properties and 18 S rDNA sequence analysis. Culture extracts of these strains were tested against KB (human epidermal carcinoma) cell line. Ankistrodesmus gracilis VACC-010 and Amphiprora alata VACC-007 showed strongest inhibition with their IC50 values of 26.50 and 29.82 ug mL^-1, respectively. Ankistrodesmus gracilis VACC-010 was also significantly effective against HepG2 (hepatocellular carcinoma) cell line (IC50, values of 9.64 ug ml^-1), suggesting a potential source of anticancer compounds. To our knowledge, this is the first report on the anticancer activity of this strain as well as the first screening of mangrove microalgae for biologically active compounds, providing a new lead to the characterization and development of promising anticancer drugs.
Chia sẻ


Hiển thị MARC

 Thông tin dữ liệu nguồn

 Thư viện  Ký hiệu xếp giá  Dữ liệu nguồn
Viện Vi sinh vật và Công nghệ Sinh học - ĐHQGHN
https://repository.vnu.edu.vn/handle/VNU_123/10597