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Acrolein / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1992

ISBN : 9241571276

Tùng thư : Environmental health criteria

Chủ đề : 1. Acrolein -- adverse effects toxicity. 2. Environmental Exposure.

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119 p. Evaluates the risks to human health and the environment posed by exposure to acrolein, a chemical produced in large quantities and used as an intermediate in the synthesis of several chemicals, most notably acrylic acid and its esters and DL-methionine, an essential amino acid used as a feed supplement for poultry and cattle. Acrolein also has direct application as an aquatic biocide used against algae, molluscs, and herbs in recirculating process water systems, irrigation channels, cooling water towers, and water treatment ponds. Acrolein is estimated to account for 3 to 10% of total automobile exhaust aldehydes, 1 to 13% of total wood-smoke aldehydes, and up to 7% of the aldehydes in cigarette smoke. Concerning sources of human exposure, the report notes that exposure of the general population occurs mainly via air, with mainstream and sidestream tobacco smoke representing the most importance source. Other sources of exposure include inhalation of air polluted by vehicle exhausts, direct contact with acrolein-treated water, and consumption of alcoholic beverages and certain food items. Concerning effects on the environment, the report cites studies documenting adverse effects on crops grown on soil irrigated by acrolein-treated water, and a very high toxicity for bacteria, algae, crustacea, and fish, with bacteria being the most sensitive species. Acrolein is noted to threaten aquatic life at or near sites of industrial discharge or spills and in areas where acrolein is used as a biocide. The most extensive section reviews the large number of studies of toxicological effects conducted in laboratory mammals and in vitro test systems. Studies support the conclusion that acrolein is acutely cytotoxic, produces teratogenic and embryotoxic effects, and is weakly mutagenic. Data on carcinogenicity were judged inadequate. In humans, case reports of accidental exposures and suicidal intoxication confirm the high toxicity of this chemical, which has its most significant effects on the eyes, nose, respiratory tract, and nervous system

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/37496

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020	__	$a9241571276
041	__	$aen
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041	__	$aes
100	__	$aInternational Programme on Chemical Safety
245	__	$aAcrolein / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization /$cInternational Programme on Chemical Safety
260	__	$bWorld Health Organization ,$c1992
490	__	$aEnvironmental health criteria $v127
520	__	$a119 p.
520	__	$aEvaluates the risks to human health and the environment posed by exposure to acrolein, a chemical produced in large quantities and used as an intermediate in the synthesis of several chemicals, most notably acrylic acid and its esters and DL-methionine, an essential amino acid used as a feed supplement for poultry and cattle. Acrolein also has direct application as an aquatic biocide used against algae, molluscs, and herbs in recirculating process water systems, irrigation channels, cooling water towers, and water treatment ponds. Acrolein is estimated to account for 3 to 10% of total automobile exhaust aldehydes, 1 to 13% of total wood-smoke aldehydes, and up to 7% of the aldehydes in cigarette smoke. Concerning sources of human exposure, the report notes that exposure of the general population occurs mainly via air, with mainstream and sidestream tobacco smoke representing the most importance source. Other sources of exposure include inhalation of air polluted by vehicle exhausts, direct contact with acrolein-treated water, and consumption of alcoholic beverages and certain food items. Concerning effects on the environment, the report cites studies documenting adverse effects on crops grown on soil irrigated by acrolein-treated water, and a very high toxicity for bacteria, algae, crustacea, and fish, with bacteria being the most sensitive species. Acrolein is noted to threaten aquatic life at or near sites of industrial discharge or spills and in areas where acrolein is used as a biocide. The most extensive section reviews the large number of studies of toxicological effects conducted in laboratory mammals and in vitro test systems. Studies support the conclusion that acrolein is acutely cytotoxic, produces teratogenic and embryotoxic effects, and is weakly mutagenic. Data on carcinogenicity were judged inadequate. In humans, case reports of accidental exposures and suicidal intoxication confirm the high toxicity of this chemical, which has its most significant effects on the eyes, nose, respiratory tract, and nervous system
650	_2	$aAcrolein $xadverse effects toxicity
650	_2	$aEnvironmental Exposure
856	__	$uhttps://iris.who.int/handle/10665/37496
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Acrolein / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Thông tin dữ liệu nguồn

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