Thư viện tập trung - Thư viện điện tử

Sách, tuyển tập

Diethylhexyl phthalate / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1992

ISBN : 9241571314

Tùng thư : Environmental health criteria

Chủ đề : 1. Diethylhexyl Phthalate -- adverse effects toxicity. 2. Environmental Exposure.

Chia sẻ

Thông tin chi tiết

Tóm tắt :

Evaluates the risks to human health and the environment posed by the production, processing, use, and disposal of diethylhexyl phthalate (DEHP). DEHP is produced in large quantities for use as a resin-softening plasticizer, with major application in the production of polyvinyl chloride used in the construction and packaging industries and in components of medical devices, including tubes used in transfusions and dialysis. Findings from over 300 recent studies were critically assessed. The opening sections characterize the behaviour of DEHP in different environmental media and summarize data indicating concentrations detected in air, precipitation, water, sediment, soil, biota, food, and the workplace environment. These studies show that, while DEHP is rapidly photodegraded in the atmosphere, aerobic biodegradation is slow, and anaerobic degradation is even slower. The report concludes that adverse effects on environmental organisms are likely in areas where water and sediment are highly contaminated. The most extensive section examines the results of numerous toxicological studies in laboratory animals and in vitro test systems. Significant findings include testicular atrophy and neoplastic effects on the liver in rats and mice. An evaluation of numerous studies on the mechanisms of hepatotoxicity concludes that the livers of rats and mice are exquisitely sensitive to DEHP and other peroxisome proliferators, while the livers of guinea-pigs, monkeys, and humans show minimal or no response. Determination of the effects of DEHP on human health was severely limited by the paucity of available data. Case reports of adverse effects linked to haemodialysis and artificial ventilation underscore the need to reduce exposure arising from the use of plastic tubes containing DEHP in such clinical procedures as transfusion, haemodialysis, and artificial respiration With summaries in French and Spanish141 p.

Chia sẻ

Hiển thị MARC

Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/37894

Ldr		00025nam a2200024 a 4500
001		CLN240809733
020	__	$a9241571314
041	__	$aen
041	__	$aja
100	__	$aInternational Programme on Chemical Safety
245	__	$aDiethylhexyl phthalate / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization /$cInternational Programme on Chemical Safety
260	__	$bWorld Health Organization ,$c1992
490	__	$aEnvironmental health criteria $v131
520	__	$aWith summaries in French and Spanish141 p.
520	__	$aEvaluates the risks to human health and the environment posed by the production, processing, use, and disposal of diethylhexyl phthalate (DEHP). DEHP is produced in large quantities for use as a resin-softening plasticizer, with major application in the production of polyvinyl chloride used in the construction and packaging industries and in components of medical devices, including tubes used in transfusions and dialysis. Findings from over 300 recent studies were critically assessed. The opening sections characterize the behaviour of DEHP in different environmental media and summarize data indicating concentrations detected in air, precipitation, water, sediment, soil, biota, food, and the workplace environment. These studies show that, while DEHP is rapidly photodegraded in the atmosphere, aerobic biodegradation is slow, and anaerobic degradation is even slower. The report concludes that adverse effects on environmental organisms are likely in areas where water and sediment are highly contaminated. The most extensive section examines the results of numerous toxicological studies in laboratory animals and in vitro test systems. Significant findings include testicular atrophy and neoplastic effects on the liver in rats and mice. An evaluation of numerous studies on the mechanisms of hepatotoxicity concludes that the livers of rats and mice are exquisitely sensitive to DEHP and other peroxisome proliferators, while the livers of guinea-pigs, monkeys, and humans show minimal or no response. Determination of the effects of DEHP on human health was severely limited by the paucity of available data. Case reports of adverse effects linked to haemodialysis and artificial ventilation underscore the need to reduce exposure arising from the use of plastic tubes containing DEHP in such clinical procedures as transfusion, haemodialysis, and artificial respiration
650	_2	$aDiethylhexyl Phthalate $xadverse effects toxicity
650	_2	$aEnvironmental Exposure
856	__	$uhttps://iris.who.int/handle/10665/37894
900		1
925		G
926		0
927		SH

Diethylhexyl phthalate / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Thông tin dữ liệu nguồn

Tài liệu cùng tác giả

WHO human health risk assessment toolkit: chemical hazards / World Health Organization;International Programme on Chemical Safety

Dermal exposure / World Health Organization;International Programme on Chemical Safety;Inter-Organization Programme for the Sound Management of Chemicals

Ultraviolet radiation / World Health Organization;International Programme on Chemical Safety

Carbon monoxide / World Health Organization;International Programme on Chemical Safety

Polychlorinated biphenyls and terphenyls / World Health Organization;International Programme on Chemical Safety

Lời ngỏ

Mục đích và phương châm hoạt động

Bản quyền