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Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and on behalf of the Commission of the European Communities / Commission of the European Communities

Tác giả : Commission of the European Communities

Nhà xuất bản : World Health Organization

Năm xuất bản : 1991

ISBN : 5225019242 (Russian); 9241571195

Tùng thư : Environmental health criteria

Chủ đề : 1. Kidney. 2. Kidney Diseases -- chemically induced. 3. Kidney Neoplasms -- drug effects.

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Establishes detailed guiding principles for the planning of studies designed to investigate the nephrotoxic effects of exposure to chemicals, whether medicinal, industrial, or environmental. Close to 800 recent reports are cited in order to provide state-of-the-art advice on the design of studies, the interpretation of results, and the extrapolation of data from animals to man. As early renal injury is often masked by the kidneys considerable functional reserve and capacity for repair, the book places special emphasis on the need for improved screening tools and markers that can aid the timely diagnosis of chemically induced renal dysfunction. The book also cites evidence that exposure to chemicals may have a much greater influence on the incidence of nephropathy and chronic renal failure than previously suspected. The book opens with a thorough discussion of the many factors that must be considered when investigating nephrotoxicity due to chemicals. The second chapter discusses the special features of kidney structure and function, including the mechanisms by which xenobiotic molecules are metabolized, that can affect the interpretation of toxicological data. Other chapters summarize current knowledge on the molecular basis of renal injury, identify specific therapeutic agents and chemicals that can induce nephrotoxicity, and outline the multiplicity of questions that must be asked in order to identify nephrotoxic chemicals and understand their potencies, sites, and mechanisms of toxicity. The concluding chapter evaluates the predictive value and diagnostic validity of new biochemical and immunochemical markers of early renal changes in humans Summary and conclusions and recommendations in French and SpanishEUR 13222 EN266 p.

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/38147

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020	__	$a5225019242 (Russian)
041	__	$aen
041	__	$aru
100	__	$aCommission of the European Communities
245	__	$aPrinciples and methods for the assessment of nephrotoxicity associated with exposure to chemicals / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and on behalf of the Commission of the European Communities /$cCommission of the European Communities
260	__	$bWorld Health Organization ,$c1991
490	__	$aEnvironmental health criteria $v119
520	__	$aSummary and conclusions and recommendations in French and SpanishEUR 13222 EN266 p.
520	__	$aEstablishes detailed guiding principles for the planning of studies designed to investigate the nephrotoxic effects of exposure to chemicals, whether medicinal, industrial, or environmental. Close to 800 recent reports are cited in order to provide state-of-the-art advice on the design of studies, the interpretation of results, and the extrapolation of data from animals to man. As early renal injury is often masked by the kidneys considerable functional reserve and capacity for repair, the book places special emphasis on the need for improved screening tools and markers that can aid the timely diagnosis of chemically induced renal dysfunction. The book also cites evidence that exposure to chemicals may have a much greater influence on the incidence of nephropathy and chronic renal failure than previously suspected. The book opens with a thorough discussion of the many factors that must be considered when investigating nephrotoxicity due to chemicals. The second chapter discusses the special features of kidney structure and function, including the mechanisms by which xenobiotic molecules are metabolized, that can affect the interpretation of toxicological data. Other chapters summarize current knowledge on the molecular basis of renal injury, identify specific therapeutic agents and chemicals that can induce nephrotoxicity, and outline the multiplicity of questions that must be asked in order to identify nephrotoxic chemicals and understand their potencies, sites, and mechanisms of toxicity. The concluding chapter evaluates the predictive value and diagnostic validity of new biochemical and immunochemical markers of early renal changes in humans
650	_2	$aKidney Diseases $xchemically induced
650	_2	$aKidney Neoplasms $xdrug effects
650	_2	$aKidney
856	__	$uhttps://iris.who.int/handle/10665/38147
900		1
925		G
926		0
927		SH

Thông tin dữ liệu nguồn

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