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Biomarkers and risk assessment : concepts and principles / published under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1993

ISBN : 5225032605 (Russian); 9241571551

Tùng thư : Environmental health criteria

Chủ đề : 1. Biomarkers. 2. Environmental Exposure. 3. Hazardous Substances. 4. Risk Factors.

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A guide to the concepts and principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection and validation of appropriate biomarkers of exposure, of toxic effect, and of susceptibility in either individuals or sub-populations. The book also explains how the use of validated biomarkers to monitor exposed populations can provide the basis for early public health interventions. The book opens with background information on the uses of biomarkers for health risk assessment, clinical diagnosis, and the monitoring of exposure, followed by a discussion of the principles and methods governing their selection and validation. The ethical and social issues that need to be considered when designing research projects are also discussed. The main part of the book sets out guidelines, supported by examples from recent research, for the selection and use of biomarkers of exposure, of effect, of carcinogenicity, and of susceptibility. For biomarkers of effect, the book concentrates on biomarkers that are currently used or under development to assess toxic effects on the hepatic, renal, haematological, immune, pulmonary, reproductive, developmental and nervous systems. For biomarkers of genotoxic carcinogens, the book describes currently available techniques using DNA adducts, protein adducts, cytogenic methods, chromosome damage, sister chromatid exchange, micronuclei, aneuploidy, and mutation. Biomarkers for non-genotoxic carcinogens are also briefly discussed. The concluding chapter, on susceptibility, alerts researchers to the many factors that can affect individual susceptibility to the toxic effects of chemicals Summary and recommendations in French and Spanish82 p.

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/39037

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100	__	$aInternational Programme on Chemical Safety
245	__	$aBiomarkers and risk assessment : concepts and principles / published under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization /$cInternational Programme on Chemical Safety
260	__	$bWorld Health Organization ,$c1993
490	__	$aEnvironmental health criteria $v155
520	__	$aSummary and recommendations in French and Spanish82 p.
520	__	$aA guide to the concepts and principles governing the use of biomarkers to assess the risks to human health posed by exposure to chemical agents. Emphasis is placed on criteria for the selection and validation of appropriate biomarkers of exposure, of toxic effect, and of susceptibility in either individuals or sub-populations. The book also explains how the use of validated biomarkers to monitor exposed populations can provide the basis for early public health interventions. The book opens with background information on the uses of biomarkers for health risk assessment, clinical diagnosis, and the monitoring of exposure, followed by a discussion of the principles and methods governing their selection and validation. The ethical and social issues that need to be considered when designing research projects are also discussed. The main part of the book sets out guidelines, supported by examples from recent research, for the selection and use of biomarkers of exposure, of effect, of carcinogenicity, and of susceptibility. For biomarkers of effect, the book concentrates on biomarkers that are currently used or under development to assess toxic effects on the hepatic, renal, haematological, immune, pulmonary, reproductive, developmental and nervous systems. For biomarkers of genotoxic carcinogens, the book describes currently available techniques using DNA adducts, protein adducts, cytogenic methods, chromosome damage, sister chromatid exchange, micronuclei, aneuploidy, and mutation. Biomarkers for non-genotoxic carcinogens are also briefly discussed. The concluding chapter, on susceptibility, alerts researchers to the many factors that can affect individual susceptibility to the toxic effects of chemicals
650	_2	$aBiomarkers
650	_2	$aEnvironmental Exposure
650	_2	$aHazardous Substances
650	_2	$aRisk Factors
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Biomarkers and risk assessment : concepts and principles / published under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Thông tin dữ liệu nguồn

WHO human health risk assessment toolkit: chemical hazards / World Health Organization;International Programme on Chemical Safety

Dermal exposure / World Health Organization;International Programme on Chemical Safety;Inter-Organization Programme for the Sound Management of Chemicals

Ultraviolet radiation / World Health Organization;International Programme on Chemical Safety

Carbon monoxide / World Health Organization;International Programme on Chemical Safety

Polychlorinated biphenyls and terphenyls / World Health Organization;International Programme on Chemical Safety

Biomarkers and risk assessment : concepts and principles / published under the joint sponsorship of the United Nations environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Thông tin dữ liệu nguồn

Tài liệu cùng tác giả

WHO human health risk assessment toolkit: chemical hazards / World Health Organization;International Programme on Chemical Safety

Dermal exposure / World Health Organization;International Programme on Chemical Safety;Inter-Organization Programme for the Sound Management of Chemicals

Ultraviolet radiation / World Health Organization;International Programme on Chemical Safety

Carbon monoxide / World Health Organization;International Programme on Chemical Safety

Polychlorinated biphenyls and terphenyls / World Health Organization;International Programme on Chemical Safety

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