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2-Nitropropane / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1992

ISBN : 9241571381

Tùng thư : Environmental health criteria

Chủ đề : 1. Environmental Exposure -- analogs and derivatives toxicity standards. 2. Propane.

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108 p. Evaluates the risks to human health and the environment posed by 2-nitropropane, an important industrial chemical used as a solvent for printing inks, paints, varnishes, adhesives, and other coatings, such as beverage container linings. 2-Nitropropane is also used in printing inks for flexible food packaging and in food processing, primarily for the separation of oleic acid from polyunsaturated fatty acids. Though smokers are regularly exposed to low concentrations, exposure of the general population from other sources is judged to be very low. The most extensive section evaluates data from studies conducted in laboratory mammals and in vitro test systems. Studies show moderate acute toxicity for mammals, with considerable variation in the sensitivity of different laboratory animals. Studies conducted in the rat provide clear evidence of destructive changes in the liver, including hepatocellular carcinoma. The report found no conclusive evidence that 2-nitropropane causes cancer in other laboratory species. Concerning effects on humans, the report notes that exposure to high concentrations, which are acutely toxic, is largely or entirely confined to the occupational setting. An evaluation of toxic effects draws upon seven reports of industrial fatalities attributed to inhalation of 2-nitropropane fumes, with death due to acute hepatic failure in all cases. Although more research on long-term effects is needed, the report notes that available data provide no indication that chronic occupational exposure at concentrations usually encountered in the workplace induces hepatic or other neoplasms, or other long-term effects. Because 2-nitropropane is a potent carcinogen in rats, the report recommends that occupational exposure to this solvent, and its presence in consumer products, be minimized and replaced with a less toxic solvent whenever practical. The report recommends against the use of 2-nitropropane in food processing

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/39519

Ldr		00025nam a2200024 a 4500
001		CLN240811232
020	__	$a9241571381
041	__	$aen
100	__	$aInternational Programme on Chemical Safety
245	__	$a2-Nitropropane / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization /$cInternational Programme on Chemical Safety
260	__	$bWorld Health Organization ,$c1992
490	__	$aEnvironmental health criteria $v138
520	__	$a108 p.
520	__	$aEvaluates the risks to human health and the environment posed by 2-nitropropane, an important industrial chemical used as a solvent for printing inks, paints, varnishes, adhesives, and other coatings, such as beverage container linings. 2-Nitropropane is also used in printing inks for flexible food packaging and in food processing, primarily for the separation of oleic acid from polyunsaturated fatty acids. Though smokers are regularly exposed to low concentrations, exposure of the general population from other sources is judged to be very low. The most extensive section evaluates data from studies conducted in laboratory mammals and in vitro test systems. Studies show moderate acute toxicity for mammals, with considerable variation in the sensitivity of different laboratory animals. Studies conducted in the rat provide clear evidence of destructive changes in the liver, including hepatocellular carcinoma. The report found no conclusive evidence that 2-nitropropane causes cancer in other laboratory species. Concerning effects on humans, the report notes that exposure to high concentrations, which are acutely toxic, is largely or entirely confined to the occupational setting. An evaluation of toxic effects draws upon seven reports of industrial fatalities attributed to inhalation of 2-nitropropane fumes, with death due to acute hepatic failure in all cases. Although more research on long-term effects is needed, the report notes that available data provide no indication that chronic occupational exposure at concentrations usually encountered in the workplace induces hepatic or other neoplasms, or other long-term effects. Because 2-nitropropane is a potent carcinogen in rats, the report recommends that occupational exposure to this solvent, and its presence in consumer products, be minimized and replaced with a less toxic solvent whenever practical. The report recommends against the use of 2-nitropropane in food processing
650	_2	$aEnvironmental Exposure $xanalogs and derivatives toxicity standards
650	_2	$aPropane
856	__	$uhttps://iris.who.int/handle/10665/39519
900		1
925		G
926		0
927		SH

2-Nitropropane / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Thông tin dữ liệu nguồn

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WHO human health risk assessment toolkit: chemical hazards / World Health Organization;International Programme on Chemical Safety

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Ultraviolet radiation / World Health Organization;International Programme on Chemical Safety

Carbon monoxide / World Health Organization;International Programme on Chemical Safety

Polychlorinated biphenyls and terphenyls / World Health Organization;International Programme on Chemical Safety

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