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The use of synthetic antigens for diagnosis of infectious diseases : report of a WHO scientific group [meeting held in Geneva from 30 November to 4 December 1987] = Uso de antígenos sintéticos para el diagnóstico de la enfermedades infecciosas : informe de un Grupo Científico de la OMS [se reunió en Ginebra del 30 de noviembre al 4 de diciembre de 1987] / World Health Organization

Tác giả : World Health Organization

Nhà xuất bản : World Health Organization

Năm xuất bản : 1989

ISBN : 9241207841

Tùng thư : World Health Organization technical report series

Chủ đề : 1. Bacterial Infections. 2. Parasitic Diseases. 3. Vaccines, Synthetic -- diagnosis. 4. Virus Diseases.

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Tóm tắt :

74 p. A state-of-the-art review of basic and applied research focused on the potential of synthetic antigens to yield more rapid and accurate diagnostic tests for infectious diseases. Addressed to researchers, the book evaluates more than 200 recent studies in an effort to define which lines of investigation are most likely to produce significant diagnostic gains. Applications in viral, bacterial, and parasitic diseases are considered together with prospects for the development of improved diagnostic tests for the detection and monitoring of infection with the human immunodeficiency virus (HIV). Throughout, an effort is made to pinpoint specific applications where the use of synthetic antigens offers distinct advantages over natural epitopes. Guidelines for the use of existing synthetic peptides are also provided. The report opens with a review of the remarkable progress achieved in chemical peptide synthesis and in the use of recombinant DNA technology for the production of antigens. An introduction to procedures for the identification of antigenic determinants is followed by a review of progress in the development of diagnostic assays at the B cell and T cell levels. Readers are then given a detailed assessment of the potential usefulness of synthetic antigens in the diagnosis of viral infections, including those caused by influenza virus, paramyxoviruses, arenaviruses, hepatitis B virus, poliovirus, hepatitis A virus, and herpesviruses. Applications in the diagnosis of HIV infection are assessed against the drawbacks of current diagnostic tests, particularly concerning the need for expensive confirmatory tests and the serious problems caused by false-negative responses. Readers learn how the ability to produce synthetic antigens has opened exciting prospects for the design of new screening reagents and the development of urgently needed assays for monitoring the progress of infection and therapy, for routinely following up asymptomatic carriers, and for establishing a prognosis for carriers and patients at various stages of disease severity. The final section reviews the potential of synthetic antigens to improve the diagnosis of bacterial and parasitic diseases. Examples explored include mycobacteria, streptococci, malaria, and schistosomiasis

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/39975

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245	__	$aThe use of synthetic antigens for diagnosis of infectious diseases : report of a WHO scientific group [meeting held in Geneva from 30 November to 4 December 1987] =$bUso de antígenos sintéticos para el diagnóstico de la enfermedades infecciosas : informe de un Grupo Científico de la OMS [se reunió en Ginebra del 30 de noviembre al 4 de diciembre de 1987] /$cWorld Health Organization
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490	__	$aWorld Health Organization technical report series $vno. 784
520	__	$a74 p.
520	__	$aA state-of-the-art review of basic and applied research focused on the potential of synthetic antigens to yield more rapid and accurate diagnostic tests for infectious diseases. Addressed to researchers, the book evaluates more than 200 recent studies in an effort to define which lines of investigation are most likely to produce significant diagnostic gains. Applications in viral, bacterial, and parasitic diseases are considered together with prospects for the development of improved diagnostic tests for the detection and monitoring of infection with the human immunodeficiency virus (HIV). Throughout, an effort is made to pinpoint specific applications where the use of synthetic antigens offers distinct advantages over natural epitopes. Guidelines for the use of existing synthetic peptides are also provided. The report opens with a review of the remarkable progress achieved in chemical peptide synthesis and in the use of recombinant DNA technology for the production of antigens. An introduction to procedures for the identification of antigenic determinants is followed by a review of progress in the development of diagnostic assays at the B cell and T cell levels. Readers are then given a detailed assessment of the potential usefulness of synthetic antigens in the diagnosis of viral infections, including those caused by influenza virus, paramyxoviruses, arenaviruses, hepatitis B virus, poliovirus, hepatitis A virus, and herpesviruses. Applications in the diagnosis of HIV infection are assessed against the drawbacks of current diagnostic tests, particularly concerning the need for expensive confirmatory tests and the serious problems caused by false-negative responses. Readers learn how the ability to produce synthetic antigens has opened exciting prospects for the design of new screening reagents and the development of urgently needed assays for monitoring the progress of infection and therapy, for routinely following up asymptomatic carriers, and for establishing a prognosis for carriers and patients at various stages of disease severity. The final section reviews the potential of synthetic antigens to improve the diagnosis of bacterial and parasitic diseases. Examples explored include mycobacteria, streptococci, malaria, and schistosomiasis
650	_2	$aVaccines, Synthetic $xdiagnosis
650	_2	$aVirus Diseases
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Thông tin dữ liệu nguồn

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Evidence gaps on unmet health and social care needs in the WHO South-East Asia region: research report / World Health Organization

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