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Assessing human health risks of chemicals : derivation of guidance values for health-based exposure limits / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization / International Programme on Chemical Safety

Tác giả : International Programme on Chemical Safety

Nhà xuất bản : World Health Organization

Năm xuất bản : 1994

ISBN : 5225032850 (Russian); 9241571705

Tùng thư : Environmental health criteria

Chủ đề : 1. Environmental Exposure. 2. Guideline. 3. Hazardous Substances -- toxicity.

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Outlines methods and procedures for the derivation of guidance values for protecting the health of humans exposed to chemical substances. Guidance values provide quantitative information from risk assessment for regulatory authorities and other risk managers, and provide a basis for the establishment of national or local exposure limits and standards. The approach described relates primarily to long-term exposure of the general opulation in the ambient environment. Addressed to all involved in chemical safety, the book aims to promote consistency in the methods used when evaluating the health effects of environmental chemicals and formulating credible conclusions. Information ranges from guidance on the use of uncertainty factors when human data are lacking, through advice on how to establish a tolerable intake when a chemical shows more than one adverse effect, to examples of cases where a guidance value should not be established. The first section introduces key terms and explains the two principal methodological concepts: development of a tolerable intake on the basis of interpretation of available toxicity data, and allocation of the proportions of the tolerable intake to various environmental media. The second section describes procedures for determining a tolerable intake on the basis of toxicity data. Section three sets out a series of steps to be followed when extrapolating from a toxicity data base to a tolerable intake, moving from selection of a pivotal study and critical effects, through interspecies extrapolation, to a final review of the total uncertainty factor. The concluding section offers advice on the allocation of tolerable intakes to derive guidance values Summary and evaluation; conclusions and recommendations also in French and English73 p.

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Thông tin dữ liệu nguồn

Thư viện	Ký hiệu xếp giá	Dữ liệu nguồn
Tổ chức y tế thế giới		https://iris.who.int/handle/10665/40675

Ldr		00025nam a2200024 a 4500
001		CLN240812256
020	__	$a9241571705
020	__	$a5225032850 (Russian)
041	__	$aen
041	__	$aja
041	__	$aru
041	__	$apl
100	__	$aInternational Programme on Chemical Safety
245	__	$aAssessing human health risks of chemicals : derivation of guidance values for health-based exposure limits / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization /$cInternational Programme on Chemical Safety
260	__	$bWorld Health Organization ,$c1994
490	__	$aEnvironmental health criteria $v170
520	__	$aSummary and evaluation; conclusions and recommendations also in French and English73 p.
520	__	$aOutlines methods and procedures for the derivation of guidance values for protecting the health of humans exposed to chemical substances. Guidance values provide quantitative information from risk assessment for regulatory authorities and other risk managers, and provide a basis for the establishment of national or local exposure limits and standards. The approach described relates primarily to long-term exposure of the general opulation in the ambient environment. Addressed to all involved in chemical safety, the book aims to promote consistency in the methods used when evaluating the health effects of environmental chemicals and formulating credible conclusions. Information ranges from guidance on the use of uncertainty factors when human data are lacking, through advice on how to establish a tolerable intake when a chemical shows more than one adverse effect, to examples of cases where a guidance value should not be established. The first section introduces key terms and explains the two principal methodological concepts: development of a tolerable intake on the basis of interpretation of available toxicity data, and allocation of the proportions of the tolerable intake to various environmental media. The second section describes procedures for determining a tolerable intake on the basis of toxicity data. Section three sets out a series of steps to be followed when extrapolating from a toxicity data base to a tolerable intake, moving from selection of a pivotal study and critical effects, through interspecies extrapolation, to a final review of the total uncertainty factor. The concluding section offers advice on the allocation of tolerable intakes to derive guidance values
650	_2	$aHazardous Substances $xtoxicity
650	_2	$aEnvironmental Exposure
650	_2	$aGuideline
856	__	$uhttps://iris.who.int/handle/10665/40675
900		1
925		G
926		0
927		SH

Thông tin dữ liệu nguồn

Tài liệu cùng tác giả

WHO human health risk assessment toolkit: chemical hazards / World Health Organization;International Programme on Chemical Safety

Dermal exposure / World Health Organization;International Programme on Chemical Safety;Inter-Organization Programme for the Sound Management of Chemicals

Ultraviolet radiation / World Health Organization;International Programme on Chemical Safety

Carbon monoxide / World Health Organization;International Programme on Chemical Safety

Polychlorinated biphenyls and terphenyls / World Health Organization;International Programme on Chemical Safety

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