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  • Efficacy of chloroquine and sulfadoxine/pyrimethamine mono-and combined therapy against falciparum malaria in Sudan / El Amin, S.B.;Malik, El F.M.;Ahmed, El D.S.;El Abadi, E.K.;Mohamad, T.A.
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Efficacy of chloroquine and sulfadoxine/pyrimethamine mono-and combined therapy against falciparum malaria in Sudan / El Amin, S.B.;Malik, El F.M.;Ahmed, El D.S.;El Abadi, E.K.;Mohamad, T.A.

Tác giả : El Amin, S.B.;Malik, El F.M.;Ahmed, El D.S.;El Abadi, E.K.;Mohamad, T.A.

Năm xuất bản : 2007

Chủ đề : 1. Chloroquine. 2. Drug Therapy, Combination. 3. Malaria, Falciparum. 4. Pyrimethamine. 5. Sulfadoxine. 6. Treatment Outcome.

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25-34 We assessed the efficacy of chloroquine and sulfadoxine/pyrimethamine monotherapy in several sentinel sites in northern Sudan and the efficacy of combined therapy in 2 sites. Chloroquine efficacy in children under 5 years was also assessed in 2 sites in southern Sudan. Patients with indications of uncomplicated falciparum malaria and sufficient parasite density were enrolled. The chloroquine failure rates in the northern and southern sites were 43.4% and 80.2% respectively. Treatment failure was significantly higher in children than adults, while there was no significant sex difference. Sulfadoxine/pyrimethamine had an overall failure rate of 4.4%. Combination of the 2 drugs had a failure rate of 14.5% and 5.9% in the 2 sites
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https://iris.who.int/handle/10665/117220