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  • Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test / El Beshlawy, A.;Kaddah, N.;Moustafa, A.;Mouktar, G.;Youssry, I.
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Screening for beta-thalassaemia carriers in Egypt: significance of the osmotic fragility test / El Beshlawy, A.;Kaddah, N.;Moustafa, A.;Mouktar, G.;Youssry, I.

Tác giả : El Beshlawy, A.;Kaddah, N.;Moustafa, A.;Mouktar, G.;Youssry, I.

Năm xuất bản : 2007

Chủ đề : 1. beta-Thalassemia. 2. Hemoglobin A2. 3. Heterozygote Detection. 4. Iron. 5. Osmotic Fragility. 6. Sensitivity and Specificity. 7. Transferrin.

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Tóm tắt :

780-786 To estimate beta-thalassaemia carrier rate and to determine an accurate mass screening test, we tested 1000 randomly selected children aged 5-16 years from different geographical areas of Egypt. Microcytosis was present in 412 participants. The osmotic fragility test was positive in 81.1% of the 90 beta-thalassaemia carriers; in the indeterminate group [12 participants], the test was positive in 83.3%; in the 310 who were iron deficient, the test was positive in 63.9%. beta-thalassaemia carrier rate was >/= 9%. Serum iron, microcytosis, HbA2 level and transferrin saturation were accurate tests for detecting carriers. For the one-tube osmotic fragility test, sensitivity was 87.0% and specificity 34.1%; the test has limited use for a mass screening programme in Egypt, where iron deficiency is prevalent
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https://iris.who.int/handle/10665/117312