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Immunohistochemical detection of p53 protein in ameloblastoma types / El Sissy, N.A.

Tác giả : El Sissy, N.A.

Năm xuất bản : 1999

Chủ đề : 1. Ameloblastoma. 2. Immunohistochemistry. 3. Mandibular Neoplasms. 4. Maxillary Neoplasms.

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Tóm tắt :

478-489 Overexpression of p53 protein in unicystic ameloblastoma [uAB] is denser than in the conventional ameloblastoma [cAB] type, indicating increased wild type p53 - suppressing the growth potential of uAB and denoting the early event of neoplastic transformation, probably of a previous odontogenic cyst. Overexpression of p53 in borderline cAB and malignant ameloblastoma [mAB] types might reflect a mutational p53 protein playing an oncogenic role, promoting tumour growth. Overexpression of p53 protein could be a valid screening method for predicting underlying malignant genetic changes in AB types, through increased frequency of immunoreactive cells or increased staining density

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https://iris.who.int/handle/10665/118731