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  • Triclabendazole in the treatment of human fascioliasis: a community-based study / El Morshedy, H.;Farghaly, A.;Sharaf, S.;Abou Basha, L.;Barakat, R.
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Triclabendazole in the treatment of human fascioliasis: a community-based study / El Morshedy, H.;Farghaly, A.;Sharaf, S.;Abou Basha, L.;Barakat, R.

Tác giả : El Morshedy, H.;Farghaly, A.;Sharaf, S.;Abou Basha, L.;Barakat, R.

Năm xuất bản : 1999

Chủ đề : 1. Anthelmintics. 2. Benzimidazoles. 3. Child, Preschool. 4. Cholestasis. 5. Chronic Disease. 6. Drug Administration Schedule. 7. Endemic Diseases. 8. Fascioliasis. 9. Liver Function Tests. 10. Treatment Outcome.

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888-894 The efficacy of triclabendazole in the treatment of chronic Fasciola infection was assessed. A total of 134 asymptomatic cases of established Fasciola infection were treated: 68 individuals received a single dose of 10 mg/kg and 66 individuals received 2 doses of 10 mg/kg on 2 consecutive days. Cure was assessed 5 weeks after treatment and 79.4% of the first group and 93.9% of the second group were cured. The drug was well tolerated; no serious side-effects were noted. One patient developed biochemical cholestasis the third day after treatment, but her enzyme profiles returned to normal after 2 months. We conclude triclabendazole is a safe and potent fasciolicidic drug
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https://iris.who.int/handle/10665/118776