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  • Long-term immunogenicity and efficacy of a recombinant hepatitis B vaccine in Egyptian children / El Sawy, I.H.;Mohamed, O.N.
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Long-term immunogenicity and efficacy of a recombinant hepatitis B vaccine in Egyptian children / El Sawy, I.H.;Mohamed, O.N.

Tác giả : El Sawy, I.H.;Mohamed, O.N.

Năm xuất bản : 1999

Chủ đề : 1. Child, Preschool. 2. Cross-Sectional Studies. 3. Hepatitis B Antibodies. 4. Hepatitis B Core Antigens. 5. Hepatitis B Surface Antigens. 6. Hepatitis B Vaccines. 7. Immunization Schedule. 8. Immunization, Secondary. 9. Time Factors. 10. Vaccines, Synthetic.

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922-932 In 1992, Egypt adopted a hepatitis B vaccine schedule at 2, 4 and 6 months of age. We evaluated the long-term immunogenicity and efficacy of vaccination using this schedule in 180 children whose time lapse since last vaccination varied between 1 month and 5 years. None of the participants had clinical hepatitis, HBsAg was not detected in any participant and all but one had negative results for anti-HBc test. Although a high seroprotection rate [93.3%] was elicited 1 month after vaccination, there were low initial anti-HBs concentrations and both declined rapidly over time. Thus, the short interval [2 months] between the second and third doses of vaccine is less desirable in the long term. We recommend booster inoculations for all previously vaccinated children and a new vaccination schedule at 1, 2 and 9 months
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https://iris.who.int/handle/10665/118780