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  • Assessment of response to tamoxifen among Iraqi patients with advanced breast cancer / Al Alwan, N.A.S.;Al Kubaisy, W.;Al Rawaq, K.
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Assessment of response to tamoxifen among Iraqi patients with advanced breast cancer / Al Alwan, N.A.S.;Al Kubaisy, W.;Al Rawaq, K.

Tác giả : Al Alwan, N.A.S.;Al Kubaisy, W.;Al Rawaq, K.

Năm xuất bản : 2000

Chủ đề : 1. Breast Neoplasms. 2. Neoplasm Invasiveness. 3. Neoplasm Metastasis. 4. Receptors, Estrogen. 5. Tamoxifen.

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475-482 Eighty-eight women presenting with locally advanced or metastatic breast cancer were treated with tamoxifen alone. Estrogen and progesterone receptors [ER and PR] were immunocytochemically analysed in mammary tumour cells obtained by fine needle sampling from 73 patients. Of the breast carcinomas, 34.2% were ER+/PR+ and 43.8% were ER-/PR-. The ER+ content increased with age in postmenopausal women. After tamoxifen treatment objective remission occurred in 39.7% of the women. The overall response rate was 53.3% in the ER+/PR- group and 73.1% in the ER+/PR+ group. However, the response elicited in a case of the ER-/PR- phenotype justified the randomized use of tamoxifen among patients in Iraq where the necessary requirements for hormone receptor assessment are almost unavailable
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https://iris.who.int/handle/10665/118893