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Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis / Kheir, M.M.

Tác giả : Kheir, M.M.

Năm xuất bản : 2000

Chủ đề : 1. Esophageal and Gastric Varices. 2. Liver Cirrhosis. 3. Praziquantel. 4. Prevalence. 5. Schistosomiasis mansoni.

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926-931 The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution
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https://iris.who.int/handle/10665/118947