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Reduction of clinical tuberculosis in HIV-infected males with isoniazid prophylaxis / Alaei, K.;Alaei, A.;Mansouri, D.

Tác giả : Alaei, K.;Alaei, A.;Mansouri, D.

Năm xuất bản : 2002

Chủ đề : 1. AIDS-Related Opportunistic. 2. Antitubercular Agents. 3. Chemoprevention. 4. Isoniazid. 5. Prevalence. 6. Prisoners. 7. Prospective Studies. 8. Skin Tests. 9. Substance Abuse, Intravenous. 10. Tuberculin. 11. Tuberculosis.

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Tóm tắt :

754-757 Isoniazid [INH] chemoprophylaxis has a positive impact on the development of clinical tuberculosis. Due to the increased prevalence of tuberculosis among HIV-infected individuals, we evaluated the effect of INH on the prevention of clinical tuberculosis in HIV-infected patients. We administered 300 mg of INH daily to 246 HIV-infected, tuberculin skin test-positive patients for 12 months. During 3 years of follow-up, 41 participants died and 94 were lost to follow up. Of the 111 patients followed for the 3 years, 12 developed tuberculosis which is lower than might be expected in an untreated group. INH prophylaxis appears to be an effective method to prevent clinical tuberculosis among HIV-infected, tuberculin skin test-positive patients

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https://iris.who.int/handle/10665/119224