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  • Prevalence of endocrine complications in beta-thalassaemia major in the Islamic Republic of Iran / Shahriari, M.;Sadjadian, N.
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Prevalence of endocrine complications in beta-thalassaemia major in the Islamic Republic of Iran / Shahriari, M.;Sadjadian, N.

Tác giả : Shahriari, M.;Sadjadian, N.

Năm xuất bản : 2003

Chủ đề : 1. Adrenal Insufficiency. 2. Aftercare. 3. beta-Thalassemia. 4. Blood Transfusion. 5. Deferoxamine. 6. Ferritins. 7. Growth Disorders. 8. Hypoparathyroidism. 9. Iron Chelating Agents.

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55-60 To identify the prevalence of endocrine dysfunction in Iranians with beta-thalassaemia, we assessed thyroid, parathyroid, pancreatic and adrenal function in 150 beta-thalassaemic patients aged 10-22 years at the Paediatrics Unit, Shiraz University of Medical Sciences. Primary hypothyroidism was found in 6.0% of patients [mean age: 14.6 +/- 1.9 years], hypoparathyroidism in 7.3% [14.5 +/- 3.2 years], type 1 diabetes mellitus in 7.3% [13.9 +/- 2.8 years] and adrenal insufficiency in 1 patient. The relatively high frequency of endocrine dysfunction found in our study may be a result of poor disease control and management in early life when irreversible tissue damage occurs due to iron overload. These findings reinforce the importance of regular follow-up of patients with beta-thalassaemia major for early detection and management of associated complications
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https://iris.who.int/handle/10665/119243