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Antiphospholipid syndrome and retinal vein occlusion in adults / Maaroufi, R.M.;Hamdi, R.;Jmili, N.;Ghorbal, M.;Hamida, Bel Hadj F.;Mahjoub, T.

Tác giả : Maaroufi, R.M.;Hamdi, R.;Jmili, N.;Ghorbal, M.;Hamida, Bel Hadj F.;Mahjoub, T.

Năm xuất bản : 2004

Chủ đề : 1. Administration, Oral. 2. Antibodies, Antiphospholipid. 3. Anticoagulants. 4. Antiphospholipid Syndrome. 5. Case-Control Studies. 6. Chi-Square Distribution. 7. Fluorescein Angiography. 8. Laser Coagulation. 9. Retinal Vein Occlusion.

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Tóm tắt :

627-632 Antiphospholipid antibodies may play and important role in the pathogenesis of retinal vascular occlusions; investigated the prevalence among 33 patients with retinal vein and artery occlusions and 80 controls. Prevalence was 33% and 5% respectively. Ophthalmic examination and fluorescein angiography showed that occlusions were due to ischaemic events. The 11 patients were diagnosed with antiphospholipid syndrome: 9 patients were treated successfully with laser photocoagulation and anticoagulant and anti-aggregant therapy. Two patients with antiphospholipid antibodies associated with resistance to activated protein C had unfavourable outcomes. Our results suggest a correlation between antiphospholipid syndrome and retinal vein occlusions; we recommend a systematic search for antiphospholipid antibodies in occlusions of unexplained origin and laser photocoagulation treatment and long-term oral anticoagulant and anti-aggregant therapy

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https://iris.who.int/handle/10665/119459