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  • Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients / Saleh, A.;Kamel, L.;Ghali, A.;Ismail, A.;El Khayat, H.
Sách, tuyển tập

Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients / Saleh, A.;Kamel, L.;Ghali, A.;Ismail, A.;El Khayat, H.

Tác giả : Saleh, A.;Kamel, L.;Ghali, A.;Ismail, A.;El Khayat, H.

Năm xuất bản : 2007

Chủ đề : 1. Ammonia. 2. Blood-Brain Barrier. 3. Early Detection. 4. Hepatic Encephalopathy. 5. Phosphopyruvate Hydratase. 6. S100 Proteins. 7. Sensitivity and Specificity.

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1114-1123 To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100beta and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy [HE]. S100beta levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100beta levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100beta may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE
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https://iris.who.int/handle/10665/117356