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  • Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major / Saffar, M.J.;Saffar, H.;Khalilian, A.R.;Naqshvar, F.
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Combination therapy with interferon and ribavirin for chronic hepatitis C infection in beta-thalassaemia major / Saffar, M.J.;Saffar, H.;Khalilian, A.R.;Naqshvar, F.

Tác giả : Saffar, M.J.;Saffar, H.;Khalilian, A.R.;Naqshvar, F.

Năm xuất bản : 2009

Chủ đề : 1. beta-Thalassemia. 2. Blood Transfusion. 3. Drug Therapy, Combination. 4. Hepatitis C, Chronic. 5. Interferons. 6. Ribavirin. 7. Treatment Outcome.

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785-791 Treatment of chronic hepatitis C virus [HCV] infection in transfusion-dependent betathalassaemia major patients is complicated by existing hepatic siderosis and the fear of ribavirinassociated haemolysis. We evaluated the efficacy and side-effects of combination interferon-alpha [INF] and ribavirin therapy for HCV-infected thalassaemia patients. A total of 17 patients were enrolled [10 nonresponders to INF monotherapy, 7 naive to treatment, mean age 23.1 years] and they received 12 months of combination therapy. The sustained virological response rate 6 months after treatment was 58.8%. Blood transfusion requirements during treatment temporarily increased by 36.6%. Combination therapy was tolerated by, and may be useful for, HCV-infected thalassaemia major patients
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https://iris.who.int/handle/10665/117699