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Acute graft-versus-host disease in thalassaemic marrow transplantation with low-dose antithymocyte globulin / Khojasteh, H.N.

Tác giả : Khojasteh, H.N.

Năm xuất bản : 1999

Chủ đề : 1. Acute Disease. 2. Bone Marrow Transplantation. 3. Cyclosporins. 4. Graft vs Host Disease. 5. Prednisolone. 6. Thalassemia. 7. Transplantation, Homologous.

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Tóm tắt :

465-469 Our unit performed transplantations on 21 classes II and III thalassaemic patients [class II patients had either hepatomegaly or portal fibrosis and class III patients had both]. We used busulfan [15 mg/kg] and cyclophosphamide [200 mg/kg]. Graft-versus-host disease [GVHD] prophylaxis was cyclosporin, prednisolone and low-dose antithymocyte globulin. Our patient data showed a low incidence of acute GVHD following transplantation. We offer this regimen as an acceptable therapy for thalassaemic patients undergoing allogeneic marrow transplantation as a safe clinical procedure, irrespective of the class of patient

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https://iris.who.int/handle/10665/118728