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  • Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran / Khojasteh, H.N.;Zakerinia, M.;Ramzi, M.;Haghshenas, M.
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Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran / Khojasteh, H.N.;Zakerinia, M.;Ramzi, M.;Haghshenas, M.

Tác giả : Khojasteh, H.N.;Zakerinia, M.;Ramzi, M.;Haghshenas, M.

Năm xuất bản : 2001

Chủ đề : 1. Anti-Inflammatory Agents. 2. beta-Thalassemia. 3. Bone Marrow Transplantation. 4. Child, Preschool. 5. Chronic Disease. 6. Graft Rejection. 7. Hypoglycemia. 8. Immunoglobulins, Intravenous. 9. Prednisolone. 10. Transplantation Conditioning.

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835-837 We report the results of allogeneic bone marrow transplantation in 26 female and 37 male patients with beta-thalassaemia major [age range: 2-17 years], performed at Namazi Hospital over the period 1992-99. In all cases, standard conditioning and immunosuppressive regimens were employed. Currently, 50 patients remain thalassaemia-free, 9 of whom have developed chronic graft-versus-host disease. There were 8 deaths among the 13 unsuccessful transplant cases: 4 due to acute uncontrollable graft-versus-host disease, and 4 to non-transplant-related causes such as hypoglycaemia, hypersensitivity reactions and advanced disease. We conclude that allogeneic bone marrow transplantation is an effective therapy for the treatment of beta-thalassaemia major, particularly for patients classified as classes I and II
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https://iris.who.int/handle/10665/119097