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Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients / El Hazmi, M.A.;Warsy, A.S.

Tác giả : El Hazmi, M.A.;Warsy, A.S.

Năm xuất bản : 1999

Chủ đề : 1. alpha-Thalassemia. 2. Anemia, Sickle Cell. 3. Autoradiography. 4. Case-Control Studies. 5. Erythrocyte Count. 6. Erythrocyte Indices. 7. Gene Deletion. 8. Gene Frequency. 9. Genetic Screening.

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1159-1164 A group of Yemeni patients with sickle-cell disease [SCD] and normal Hb AA individuals living in Riyadh were studied to determine the incidence of the alpha-gene molecular defect. Blood samples were obtained from 26 SCD patients and 19 controls [the Hb AA group]. In the SCD patients the frequency of single alpha-gene deletion [-alpha/alpha alpha] was 0.346, compared to 0.263 in the Hb AA group. The frequency of two gene deletion [-alpha/-alpha] was 0.231 [0.0 for the Hb AA group]. In one Hb AA case, a triple alpha-gene arrangement [alpha alpha alpha/alpha alpha] was found [frequency 0.053]. The results suggest that alpha-thalassaemia occurs frequently in Yemeni SCD patients. Further studies to determine the overall frequency of alpha-thalassaemia in the Republic of Yemen would be of value for patient management
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https://iris.who.int/handle/10665/118811