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Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism / El Hazmi, M.A.;Warsy, A.S.

Tác giả : El Hazmi, M.A.;Warsy, A.S.

Năm xuất bản : 1999

Chủ đề : 1. Anemia, Sickle Cell. 2. Case-Control Studies. 3. Deoxyribonucleases, Type II Site-Specific. 4. Erythrocyte Count. 5. Erythrocyte Indices. 6. Globins. 7. Hemoglobin A. 8. Hemoglobin, Sickle. 9. Polymorphism, Genetic. 10. Severity of Illness Index.

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1183-1187 Our studies of the Saudi population have shown that in patients with mild presentation of sickle-cell disease [SCD] from Saudi Arabia's eastern region, the prevalence of polymorphic sites is high. However, the prevalence is very low in patients with severe SCD from the south-west of the country. We expanded these studies to a group of Yemeni patients with severe SCD, resident in Riyadh. We investigated a total of 60 chromosomes carrying the sickle-cell [Hb S] gene and 14 chromosomes carrying the Hb A gene. Amongst the Hb AA group, the prevalence was 42.9% and 57.1% for the presence [+] and absence [-] of Xmn I polymorphic sites. In the Hb SS individuals, the prevalence of Xmn I polymorphic sites was similar to the prevalence reported in the south-western region of Saudi Arabia
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https://iris.who.int/handle/10665/118815