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  • Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester / Adam, I.;Idris, H.M.;El Bashir, M.I.
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Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester / Adam, I.;Idris, H.M.;El Bashir, M.I.

Tác giả : Adam, I.;Idris, H.M.;El Bashir, M.I.

Năm xuất bản : 2004

Chủ đề : 1. Administration, Oral. 2. Antimalarials. 3. Chloroquine. 4. Drug Resistance. 5. Endemic Diseases. 6. Gestational Age. 7. Parasite Egg Count. 8. Pregnancy Outcome.

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Tóm tắt :

560-565 A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [mean gestational age 8.5 weeks] were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [3.8%] and 2 patients [7.7%] experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy
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https://iris.who.int/handle/10665/119449