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Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan / Adam, I.;Mirghani, O.A.;Saed, O.K.;Ahmed, S.M.;Mohamadani, A.A.;Ahmed, H.M.;Mackenzie, C.D.;Homeida, M.M.A.;El Bashir, M.I.

Tác giả : Adam, I.;Mirghani, O.A.;Saed, O.K.;Ahmed, S.M.;Mohamadani, A.A.;Ahmed, H.M.;Mackenzie, C.D.;Homeida, M.M.A.;El Bashir, M.I.

Năm xuất bản : 2004

Chủ đề : 1. Administration, Oral. 2. Antimalarials. 3. Body Temperature. 4. Drug Administration Schedule. 5. Gestational Age. 6. Infusions, Intravenous. 7. Pregnancy Outcome.

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Tóm tắt :

159-166 A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term [39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C]. There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancy

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https://iris.who.int/handle/10665/119396